Phospho-BRAF (Thr401) Recombinant Rabbit mAb - diagbio | 戴格生物

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Phospho-BRAF (Thr401) Recombinant Rabbit mAb

db11119

Product Name : Phospho-BRAF (Thr401) Recombinant Rabbit mAb

Cat.No.: db11119

Synonyms : NS7; B-raf; BRAF1; RAFB1; B-RAF1

Application : WB, ICC/IF, IP

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Thr401 of human B Raf
Gene ID 673
Swiss Prot P15056
Synonyms NS7; B-raf; BRAF1; RAFB1; B-RAF1
Reactivity Human, Mouse, Rat
Application WB, ICC/IF, IP
Recommended dilution WB: 1:1000
ICC/IF: 1:50
IP: 1:20
Calculated MW 84 kDa
Observed MW 84 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of Phospho-BRAF (Thr401) in K562,C6,3T3,Hela cell lysates using Phospho-BRAF (Thr401) antibody(1:1000 diluted).

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