研究领域 Research Field
细胞凋亡 查看所有相关产品
Caspase家族

Caspase Family

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Bcl-2家族

Bcl-2 Family

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细胞凋亡(apoptosis)指为维持内环境稳定,由基因控制的细胞自主的有序的死亡。细胞凋亡与细胞坏死不同,细胞凋亡是一个主动的过程,它涉及一系列基因的激活、表达以及调控等的作用,它并不是病理条件下,自体损伤的一种现象,而是为更好地适应生存环境而主动争取的一种死亡过程。细胞凋亡是细胞的一种基本生物学现象,在多细胞生物去除不需要的或异常的细胞中起着必要的作用。它在生物体的进化、内环境的稳定以及多个系统的发育中起着重要的作用。细胞凋亡不仅是一种特殊的细胞死亡类型,而且具有重要的生物学意义及复杂的分子生物学机制。

 

细胞凋亡的过程大致分为一下几个阶段

接受凋亡信号  →  凋亡调控分子间相互作用  →  蛋白水解酶的活化  →  进入连续反应的过程
Caspase家族

含半胱氨酸的天冬氨酸蛋白水解酶(cysteinyl aspartate specific proteinase,Caspase ),是一类对底物天门冬氨酸部位有特异水解作用、活性中心含半胱氨酸的蛋白酶,其在天冬氨酸残基的C-末端侧切割其靶点。Caspase蛋白酶均有以下特点:①总是在天冬氨酸之后切断底物,所以命名为Caspase(cysteine aspartate-specific protease)。②酶活性依赖于半胱氨酸残基的亲核性。③通常以酶原的形式存在,为由两大、两小亚基两两组成的异四聚体。大、小亚基由同一基因编码,在受到激活后前体被切割,产生两个活性亚基。这些蛋白酶是引起细胞凋亡的关键酶,一旦信号转导途径被激活,Caspase被活化,随后发生凋亡蛋白酶的级联反应。细胞内的酶被激活,可降解细胞内的重要蛋白质,最终导致细胞不可逆地走向凋亡。Caspase凋亡蛋白酶家族分为三类:1)第一类:凋亡启动作用;2)第二类:凋亡效应作用;3)第三类:炎性Caspase酶对于细胞凋亡通路,我们主要关注以上的第一类和第二类Caspase蛋白。从以上分类我们看出Caspase酶在细胞凋亡过程中,一类是信号启动者(或者传递信号),另外一类则行使凋亡执行的作用。所以这个家族的蛋白在细胞凋亡过程中起着核心的作用。

靶标 产品货号 产品名称 反应种属 应用
死亡受体相关 db6064 Fas (4C3) Mouse mAb Human WB
db7798 Fas Rabbit pAb Human WB,IHC,ICC/IF,FC
db12190 Fas Recombinant Rabbit mAb Human WB,IHC,ICC/IF,FC
db8788 TNF Receptor I Rabbit pAb Human WB,FC
db6178 TNFRSF10B (7F4) Mouse mAb Human,Mouse WB,ICC/IF
db8437 DR5 Rabbit pAb Human WB,ICC/IF,FC,IP
db7259 DR5 Rabbit pAb Human WB,IHC,IP
db11505 FADD Recombinant Rabbit mAb Mouse WB, IHC, FC
db11195 FADD Recombinant Rabbit mAb Human WB,IHC,ICC/IF,FC,IP
db77 FADD Rabbit pAb Mouse WB,IHC,FC
db1997 FADD Rabbit pAb Human WB,IHC,ICC/IF,FC,IP
db6467 PARP1 (10C2) Mouse mAb Human,Mouse,Rat WB,IHC-P
db1841 PARP1 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
db1970 PARP1 Rabbit pAb Human WB
db3085 PARP1 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF
db11121 PARP1 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF
db3552 Cleaved PARP1 Rabbit pAb Human WB,ICC/IF,FC,IP
db8044 Cleaved PARP1 Rabbit pAb Human,Mouse,Rat WB,IHC
db12579 Cleaved PARP1 Recombinant Rabbit mAb Human WB,ICC/IF,FC,IP
db5914 Lamin A/C Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db20155 Lamin A/C Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
db13193 Lamin A/C Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db11008 Lamin A/C Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
db22943 ICAD Rabbit pAb Human WB,IP
db21899 ICAD Rabbit pAb Human WB,IHC,ICC/IF,FC,IP
db2535 ICAD Rabbit pAb Human,Mouse,Rat WB
db14902 ICAD Recombinant Rabbit mAb Human WB,IP
db13371 ICAD Recombinant Rabbit mAb Human,Mouse,Rat WB
db4228 ROCK1 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db1651 ROCK1 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db13063 ROCK1 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db11120 ROCK1 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db562 ROCK2 Rabbit pAb Human,Mouse,Rat WB,ICC/IF
db11967 ROCK2 Recombinant Rabbit mAb Human,Mouse,Rat WB,ICC/IF
Caspase凋亡启动子 db21696 Caspase-2 Rabbit pAb Human,Mouse,Rat WB
db21794 Caspase-2 Rabbit pAb Human WB
db1826 Caspase-2 Rabbit pAb Human WB
db201 Caspase-8 Rabbit pAb Human WB,IHC,ICC/IF
db1571 Caspase-8 Rabbit pAb Human WB
db1791 Caspase-8 Rabbit pAb Human WB,ICC/IF,FC
db11621 Caspase-8 Recombinant Rabbit mAb Human WB,ICC/IF,FC
db21445 Caspase-9 Rabbit pAb Mouse,Rat WB,IP
db21959 Caspase-9 Rabbit pAb Human WB,IHC,FC
db12919 Caspase-9 Recombinant Rabbit mAb Mouse,Rat WB,IP
db12902 Caspase-9 Recombinant Rabbit mAb Human WB,IHC,FC
db2957 Caspase-10 Rabbit pAb Human WB,IHC,FC,IP
db12792 Caspase-10 Recombinant Rabbit mAb Human WB,IHC,FC,IP
Caspase凋亡效应器 db9853 Caspase-3 Rabbit pAb Mouse WB
db2059 Caspase-3 Rabbit pAb Human WB,IHC,ICC/IF,FC,IP
db3108 Caspase-3 Rabbit pAb Human,Mouse,Rat WB,IHC,IP
db14868 Caspase-3 Recombinant Rabbit mAb Mouse WB
db12058 Caspase-3 Recombinant Rabbit mAb Human WB,IHC,ICC/IF,FC,IP
db13235 Caspase-3 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,IP
db20827 Caspase-6 Rabbit pAb Human, Mouse WB,IHC,ICC/IF,FC
db12533 Caspase-6 Recombinant Rabbit mAb Human, Mouse WB,IHC,ICC/IF,FC
db22277 Caspase-7 Rabbit pAb Human WB,IHC,ICC/IF
db9717 Caspase-7 Rabbit pAb Human,Mouse,Rat WB,IHC,FC
db14082 Caspase-7 Recombinant Rabbit mAb Human WB,IHC,ICC/IF
db13106 Caspase-7 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,FC
db5308 Caspase-1 Rabbit pAb Human WB,IP
Caspase其他蛋白 db1034 Caspase-1 Rabbit pAb Human,Mouse,Rat WB,IHC
db12385 Caspase-1 Recombinant Rabbit mAb Human WB,IP
线粒体相关 db2124 Caspase-11 Rabbit pAb Mouse WB,IP
db14701 Caspase-11 Recombinant Rabbit mAb Mouse WB,IP
db6489 Cytochrome C (7C10) Mouse mAb Human,Mouse,Rat,Chicken WB,ICC/IF,IHC-P
db2293 Cytochrome C Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db2621 Cytochrome C Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db11926 Cytochrome C Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db12144 Cytochrome C Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db8521 APAF1 Rabbit pAb Human,Mouse,Rat WB,IP
db6267 AIF (8H1) Mouse mAb Human WB,ICC/IF
db21018 Endo G Rabbit pAb Human,Mouse,Rat WB
db5527 XIAP Rabbit pAb Human,Mouse,Rat WB
db11787 XIAP Recombinant Rabbit mAb Human,Mouse,Rat WB
db1637 SMAC Recombinant Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db11117 SMAC Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db492 ATF-4 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
应激DNA损伤相关 db3131 DDIT3 Rabbit pAb Human,Mouse,Rat WB,IHC
db11608 DDIT3 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC
db2934 Calpain 1 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
db8572 JNK1 Rabbit pAb Human,Mouse,Rat WB
db58 JNK1 Rabbit pAb Human,Mouse,Rat WB
db13511 JNK1 Recombinant Rabbit mAb Human,Mouse,Rat WB
db12544 JNK1 Recombinant Rabbit mAb Human,Mouse,Rat WB
db14225 JNK1/JNK2/JNK3 Recombinant Rabbit mAb Human,Mouse,Rat WB,ICC/IF,FC,IP
db12713 JNK1/JNK2/JNK3 Recombinant Rabbit mAb Human,Mouse,Rat WB,ICC/IF,FC,IP
db3253 Phospho-JNK1/JNK2/JNK3 (Thr183/Thr183/Thr221) Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db2618 JNK1/JNK2/JNK3 Rabbit pAb Human,Mouse,Rat WB,ICC/IF,FC,IP
db3352 JNK1/JNK2/JNK3 Rabbit pAb Human,Mouse,Rat WB,ICC/IF,FC,IP
db13968 JNK2 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,FC,IP
db3780 JNK2 Rabbit pAb Human,Mouse,Rat WB,IHC,FC,IP
db22741 JNK3 Rabbit pAb Human,Mouse,Rat WB,ICC/IF,FC
db20141 Phospho-JNK1 (Thr183/Tyr185) Rabbit pAb Human WB,IP
db11220 Phospho-JNK1 (Thr183/Tyr185) Recombinant Rabbit mAb Human WB,IP
db9894 p53 Rabbit pAb Mouse WB,ICC/IF,FC,IP
db9370 p53 Rabbit pAb Mouse WB,ICC/IF,FC,IP
db488 p53 Rabbit pAb Human WB,ICC/IF
db3246 p53 Rabbit pAb Human WB,IHC,ICC/IF
db14679 p53 Recombinant Rabbit mAb Mouse WB,ICC/IF,FC,IP
db12023 p53 Recombinant Rabbit mAb Human WB,ICC/IF
Bcl-2家族

B细胞淋巴瘤/白血病-2基因(B cell lymphoma/leukemia -2 gene,Bcl-2)是一种癌基因,是调节细胞凋亡的重要蛋白家族,其既有促凋亡蛋白(BH3-Only、BH 1-3等),也有抑凋亡蛋白(Bcl-2,Bcl-w等)家族,这两类蛋白在细胞凋亡过程中相互协调,通过介导线粒体途径的信号通路共同决定细胞是否进入凋亡程序,线粒体凋亡的第一个调节步骤由Bcl-2家族蛋白介导。Bcl-2家族分为三类:(1)抑凋亡蛋白,Bcl2、Bcl-xL、Mcl-1;(2)促凋亡蛋白,含有BH1/2/3结构域,包括Bax和Bak;(3)促凋亡蛋白,也称为凋亡引发亚族(apoptosis initiator group),由仅含BH3结构域的蛋白质组成,包括Bad、Bid、Bim、Puma和Noxa。因为BH3结构域的存在,此类蛋白可以与前两类Bcl2家族的蛋白相互作用,从而起到促凋亡的作用。

靶标 产品货号 产品名称 反应种属 应用
Bcl-2 db176 Bcl-2 Rabbit pAb Human WB,IHC,ICC/IF,FC,IP
db2374 Bcl-2 Rabbit pAb Human, Mouse WB,IHC,ICC/IF,FC
db225 Bcl-XL Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db2797 MCL1 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db915 Bad Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db1242 Bak Rabbit pAb Human WB,IHC,ICC/IF,FC,IP
db4336 Bok Rabbit pAb Human,Mouse,Rat WB,FC
db3766 Bok Rabbit pAb Human, Rat WB,IP
db6393 Bid (3C5) Mouse mAb Human WB,ICC/IF,FC
db836 Bim Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db7684 Noxa Rabbit pAb Human WB
db3761 PUMA Rabbit pAb Human WB,IHC,ICC/IF,FC
其他凋亡抑制相关 db5728 AKT Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db14851 Phospho-AKT1 (Ser473) Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF
db758 ERK1/2 Rabbit pAb Human,Mouse,Rat WB,ICC/IF,FC,IP
db1717 Phospho-ERK1 (pThr202/pTyr204) / ERK2 (pThr185/pTyr187) Rabbit pAb Human WB,IHC,ICC/IF,FC
db8853 Phospho-ERK1 (pThr202/pTyr204) / ERK2 (pThr185/pTyr187) Rabbit pAb Human,Mouse,Rat WB,IP
db6456 NF-kB p65 (3D2) Mouse mAb Human,Mouse,Rat WB,IHC-F,IHC-P,ICC/IF,IPP,ICC/IF,IP
db13524 NF-kB p65 Recombinant Rabbit mAb Human WB,ICC/IF,FC
db8358 NF-kB p65 Rabbit pAb Human WB,ICC/IF,FC
db3141 NF-kB p65 Rabbit pAb Human,Mouse WB,IHC,ICC/IF,FC,IP
db11612 NF-KB p65 Recombinant Rabbit mAb Human,Mouse WB,IHC,ICC/IF,FC,IP
db7996 Phospho-NF-kB p65 (Ser536) Rabbit pAb Human WB,IP