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缺氧信号转导

Hypoxia signal transduction

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动物细胞对氧气的感知和反应是—个非常重要的过程,而缺氧 (Hypoxia) 是指细胞氧气消耗和血管氧气输送失衡,所致的细胞内氧气含量和压力低于正常水平的生理情况。 短暂的缺氧可以诱导许多基因的表达,促进组织修复;长期慢性缺氧则会引发功能障碍,造成伤害。在自然界中,生物已经进化出适应缺氧的机制,该过程主要由缺氧诱导因子 (HIF) 复合物进行调控,该复合物在哺乳动物的发育、生理和疾病发病机理中起着至关重要的作用。

缺氧因子

缺氧诱导因子(HIF)是最主要的能够应答细胞内氧气浓度的降低而对多种基因进行调控的转录因子家族,与生物体的生长、发育及一些疾病的发病机理都存在着密切的关系。研究表明,缺氧因子是由α亚基和β亚基组成具有转录活性的异源二聚体。其中α亚基(HIF-α)严格受到氧气浓度调控,是缺氧因子的调节亚基,而β亚基(HIF-β)则持续性表达。因此,对于缺氧因子的主要研究集中在HIF-α。

缺氧信号转导

细胞缺氧条件下

在氧气浓度较低时,脯氨酸羟化酶(PHD)没有氧气作为底物,导致HIF-α泛素化无法进行,细胞内的泛素化酶(VHL)无法识别未泛素化的HIF-α进行降解,则导致HIF-α聚集在细胞内。聚集的HIF-α与HIF-β结合,形成有启动转录活性的HIF复合物。在细胞核中,HIF复合物与缺氧反应基因启动子区上的缺氧反应元件(HRE)结合,募集其他转录因子,激发下游的基因的表达。同时,质膜上的多种受体就会通过各种信号通路,上调HIF-α水平,促进缺氧相关基因表达。

靶点 产品货号 产品名称 反应种属 应用
HIF db489 HIF-1-alpha Rabbit pAb Human WB,IHC,ICC/IF,FC,IP
db794 HIF-1-alpha Rabbit pAb Human,Mouse WB,ICC/IF
db526 HIF-2-alpha Rabbit pAb Human WB,IHC
db22517 HIF1 beta Rabbit pAb Human,Mouse,Rat WB,IHC,FC
db12161 HIF1 beta Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,FC
PIK3K db6611 PI3-Kinase p85 alpha (1C8) Mouse mAb Human,Mouse,Rat WB,IHC-P
db6610 PI3-Kinase p85 alpha (3H5) Mouse mAb Human,Mouse,Rat WB,IHC-P
db6187 PI3-Kinase p85 beta (8D9) Mouse mAb Human WB
db1678 PI3-Kinase p110 beta Rabbit pAb Human WB,FC,IP
db3038 PI3-Kinase p110 beta Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
db11128 PI3 Kinase p110 beta Recombinant Rabbit mAb Human WB,FC,IP
AKT db6344 AKT1/2/3 Mouse mAb Human,Mouse,Rat WB,IP
db6565 AKT1/2/3 (2A1) Mouse mAb Human,Mouse,Rat IHC-P
db5728 AKT1/2/3 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db11977 AKT1/2/3 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
mTOR db7351 Phospho-mTOR (Ser2448) Rabbit pAb Human,Mouse WB,IHC
db11887 Phospho-mTOR (Ser2448) Recombinant Rabbit mAb Human, Mouse WB,IHC
db2436 Phospho-mTOR (Ser2481) Rabbit pAb Human,Mouse,Rat WB
db8578 mTOR Rabbit pAb Human,Mouse,Rat WB
db2001 mTOR Rabbit pAb Human,Mouse,Rat WB,IHC,IP
JAK-STAT db6132 JAK1 (7B1) Mouse mAb Human,Rat WB,IP
db6133 JAK1 (8B8) Mouse mAb Human,Mouse WB,ICC/IF,IP
db2764 Phospho-JAK1 (Tyr1022/Tyr1023) Rabbit pAb Human WB,IHC
db9826 JAK1 Rabbit pAb Human,Mouse,Rat WB
db6630 JAK1 (8D8) Mouse mAb Human,Mouse,Rat IHC-P
db6223 JNK1 (1A4) Mouse mAb Human,Monkey WB,ICC/IF
db6585 JAK2 (6B4) Mouse mAb Human,Mouse,Rat IHC-P
db6584 JAK2 (7H5) Mouse mAb Human,Mouse,Rat IHC-P
db1627 Phospho-JAK2 (Tyr1007/Tyr1008) Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db3405 JAK2 Rabbit pAb Human,Mouse,Rat WB,ICC/IF
db14880 JAK2 Recombinant Rabbit mAb Human,Mouse,Rat WB,ICC/IF
db6208 STAT3 (4C8) Mouse mAb Human,Mouse,Rat WB
db6555 Phospho-STAT3 (Tyr705) (5E9) Mouse mAb Human IHC-P
db6609 STAT3 (6H10) Mouse mAb Human,Mouse,Rat WB,IHC-P
db2704 Phospho-STAT3 (Ser727) Rabbit pAb Human,Rat WB,IHC,ICC/IF
db12152 Phospho-STAT3 (Ser727) Recombinant Rabbit mAb Human,Rat WB,IHC,ICC/IF
db2536 Phospho-STAT3 (Tyr705) Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db7769 STAT3 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
db1086 STAT3 Rabbit pAb Human WB,IHC,ICC/IF,FC,IP
db1650 STAT3 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
db12896 STAT3 Recombinant Rabbit mAb Human WB,IHC,ICC/IF,FC,IP
NF-κB db6428 NF-kB p65 (5A10) Mouse mAb Human,Mouse,Rat WB,IHC-P,IP
db3028 Phospho-NF-kB p65 (Ser276) Rabbit pAb Human WB,ICC/IF,IP
db508 Phospho-NF-kB p65 (Ser311) Rabbit pAb Human WB
db7996 Phospho-NF-kB p65 (Ser536) Rabbit pAb Human WB,IP
db8358 NF-kB p65 Rabbit pAb Human WB,ICC/IF,FC
db3141 NF-kB p65 Rabbit pAb Human,Mouse WB,IHC,ICC/IF,FC,IP
db13524 NF-kB p65 Recombinant Rabbit mAb Human WB,ICC/IF,FC
db11612 NF-kB p65 Recombinant Rabbit mAb Human, Mouse WB,IHC,ICC/IF,FC,IP
db6456 NF-kB p65 (3D2) Mouse mAb Human,Mouse,Rat WB,IHC-F,IHC-P,ICC/IF,IP
db6589 Acetyl-NF-kB p65 (Lys314/Lys315) (5F4) Mouse mAb Human,Mouse,Rat IHC-P
db6590 Acetyl-NF-kB p65 (Lys314/Lys315) (6D6) Mouse mAb Human,Mouse,Rat IHC-P
eIF4E  db6264 eIF4E (8C8) Mouse mAb Human,Mouse,Rat WB
db8101 Phospho-eIF4E (Ser209) Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db11218 Phospho-eIF4E (Ser209) Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db5468 eIF4E Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db7770 eIF4E Rabbit pAb Human,Mouse,Rat WB,IHC,FC,IP
db13610 eIF4E Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db11590 eIF4E Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,FC,IP

 

细胞正常氧气条件下

细胞在氧气含量正常的情况下,HIF-α在依赖于氧气的PHD的脯氨酸残基上羟基化和依赖于氧气的HIF1AN的天冬氨酸残基上羟基化。羟基化的HIF-α与VHL肿瘤抑制蛋白(pVHL),将HIF-α进行降解,从而减少HIF-α浓度。此外,在不缺氧气的情况下,HIF-α还会被其他物质抑制转录活性,阻断缺氧信号的传递。

靶标 产品货号 产品名称 反应种属 应用
PHD db5389 PHD3 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db11933 PHD3 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
FIH db21250 HIF1AN/FIH-1 Rabbit pAb Human,Mouse,Rat WB,FC
db13431 HIF1AN Recombinant Rabbit mAb Human WB,IHC,ICC/IF,FC
db20841 HIF1AN Rabbit pAb Human WB,IHC,ICC/IF,FC
GSK-3β db2986 Phospho-GSK3 (alpha/beta) (Tyr216/Tyr279) Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db13049 Phospho-GSK3 (alpha/beta) (Tyr216/Tyr279) Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db2953 GSK3 (alpha/beta) Rabbit pAb Human,Mouse,Rat WB
db14079 GSK3 (alpha/beta) Recombinant Rabbit mAb Human,Mouse,Rat WB
db14079 GSK3 (alpha/beta) Recombinant Rabbit mAb Human,Mouse,Rat WB
db6073 GSK3 beta (2E6) Mouse mAb Human,Mouse,Rat WB,ICC/IF,IP,FC
db6551 GSK3 beta (4C4) Mouse mAb Human,Mouse,Rat WB,IHC-P
db6550 GSK3 beta (9B1) Mouse mAb Human,Mouse,Rat WB,IHC-P
db6549 GSK3 beta (9F9) Mouse mAb Human,Mouse,Rat WB,IHC-P
db1715 Phospho-GSK3 beta (Ser9) Rabbit pAb Human WB,IHC,ICC/IF
db13257 Phospho-GSK3 beta (Ser9) Recombinant Rabbit mAb Human WB,IHC,ICC/IF
db13257 Phospho-GSK3 beta (Ser9) Recombinant Rabbit mAb Human WB,IHC,ICC/IF
db6410 GSK3 beta Mouse mAb Human,Mouse WB,IHC-P,FC
db2634 GSK3 beta Rabbit pAb Human,Mouse WB,IHC,ICC/IF,FC
db14808 GSK3 beta Recombinant Rabbit mAb Human,Mouse WB,IHC,ICC/IF,FC
db14808 GSK3 beta Recombinant Rabbit mAb Human,Mouse WB,IHC,ICC/IF,FC
β-catenin db6360 beta Catenin (5D6) Mouse mAb Human,Mouse,Rat WB
db1772 beta Catenin Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db2829 beta Catenin Rabbit pAb Human,Mouse,Rat WB,ICC/IF,FC
db13925 beta Catenin Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db11055 beta Catenin Recombinant Rabbit mAb Human,Mouse,Rat WB,ICC/IF,FC
db20715 Phospho-beta Catenin (Ser37) Rabbit pAb Human,Rat WB
db21020 Phospho-beta Catenin (Thr41/Ser45) Rabbit pAb Human WB,IP
p53 db9894 p53 Rabbit pAb Mouse WB,ICC/IF,FC,IP
db9370 p53 Rabbit pAb Mouse WB,ICC/IF,FC,IP
db14679 p53 Recombinant Rabbit mAb Mouse WB,ICC/IF,FC,IP
db5327 Phospho-p53 (Ser15) Rabbit pAb Human WB,IHC,ICC/IF,IP
db3404 Phospho-p53 (Ser37) Rabbit pAb Human WB
db8261 Acetyl-p53 (Lys370) Rabbit pAb Human,Mouse,Rat WB,ICC/IF,FC,IP
db11223 Acetyl-p53 (Lys370) Recombinant Rabbit mAb Human,Mouse,Rat WB,ICC/IF,FC,IP
db6593 Acetyl-p53 (Lys382) (2G4) Mouse mAb Human,Mouse,Rat IHC-P
db6592 Acetyl-p53 (Lys382) (3E3) Mouse mAb Human,Mouse,Rat IHC-P
db6591 Acetyl-p53 (Lys382) (7E1) Mouse mAb Human,Mouse,Rat IHC-P
db1766 Acetyl-p53 (Lys382) Rabbit pAb Human WB,ICC/IF,FC