Phospho-Cyclin D1 (Thr286)/Cyclin D2 (Thr280) Recombinant Rabbit mAb - diagbio

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Phospho-Cyclin D1 (Thr286)/Cyclin D2 (Thr280) Recombinant Rabbit mAb

db12610

Product Name : Phospho-Cyclin D1 (Thr286)/Cyclin D2 (Thr280) Recombinant Rabbit mAb

Cat.No.: db12610

Synonyms : BCL1; PRAD1; U21B31; D11S287E

Application : WB

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Thr286 of human Cyclin D1
Gene ID 595
Swiss Prot P24385
Synonyms BCL1; PRAD1; U21B31; D11S287E
Reactivity Human, Mouse, Rat
Application WB
Recommended dilution WB: 1:1000
Calculated MW 34 kDa
Observed MW 36 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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