Phospho-BCAR1 (Tyr410) Recombinant Rabbit mAb - diagbio | 戴格生物

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Phospho-BCAR1 (Tyr410) Recombinant Rabbit mAb

db12641

Product Name : Phospho-BCAR1 (Tyr410) Recombinant Rabbit mAb

Cat.No.: db12641

Synonyms : CAS; CAS1; CASS1; CRKAS; P130Cas

Application : WB, IP

Reactivity : Human

Host species : Rabbit

Background The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Tyr410 of human BCAR1
Gene ID 9564
Swiss Prot P56945
Synonyms CAS; CAS1; CASS1; CRKAS; P130Cas
Reactivity Human
Application WB, IP
Recommended dilution WB: 1:1000
IP: 1:20
Calculated MW 93 kDa
Observed MW 130 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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