Phospho-PTP1B (Ser352) Rabbit pAb
Product Name :
Phospho-PTP1B (Ser352) Rabbit pAb
Cat.No.:
db1275
Synonyms :
PTP1B
Application :
WB, ICC/IF, IP
Reactivity :
Human
Host species :
Rabbit
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Background
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
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Immunogen
A synthetic phosphopeptide corresponding to residues surrounding
Ser352 of human PTP1B
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Gene ID
5770
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Swiss Prot
P18031
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Synonyms
PTP1B
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Reactivity
Human
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Application
WB, ICC/IF, IP
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Recommended dilution
WB: 1:1000
ICC/IF: 1:50
IP: 1:20
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Calculated MW
50 kDa
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Observed MW
50 kDa
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Host species
Rabbit
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Clonality
Polyclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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20μL
698
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50μL
1398
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100μL
2398
- 货期:现货
For research use only. Not intended for diagnostic.