Phospho-PRK1/PRK2/PRK3 (Thr774/Thr816/Thr718) Recombinant Rabbit mAb - diagbio

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Phospho-PRK1/PRK2/PRK3 (Thr774/Thr816/Thr718) Recombinant Rabbit mAb

db14035

Product Name : Phospho-PRK1/PRK2/PRK3 (Thr774/Thr816/Thr718) Recombinant Rabbit mAb

Cat.No.: db14035

Synonyms : DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA

Application : WB, FC

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Thr774 of human PRK1
Gene ID 5585
Swiss Prot Q16512
Synonyms DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA
Reactivity Human, Mouse, Rat
Application WB, FC
Recommended dilution WB: 1:1000
FC: 1:20
Calculated MW 104,112,99 kDa
Observed MW 120-140 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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