Phospho-Bcr (Tyr177) Recombinant Rabbit mAb
Product Name :
Phospho-Bcr (Tyr177) Recombinant Rabbit mAb
Cat.No.:
db14074
Synonyms :
ALL; CML; PHL; BCR1; D22S11; D22S662
Application :
WB
Reactivity :
Human
Host species :
Rabbit
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Background
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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Immunogen
A synthetic phosphopeptide corresponding to residues surrounding
Tyr177 of human Bcr
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Gene ID
613
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Swiss Prot
P11274
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Synonyms
ALL; CML; PHL; BCR1; D22S11; D22S662
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Reactivity
Human
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Application
WB
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Recommended dilution
WB: 1:1000
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Calculated MW
143 kDa
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Observed MW
160 kDa
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Host species
Rabbit
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Clonality
Monoclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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20μL
698
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50μL
1398
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100μL
2398
- 货期:现货
For research use only. Not intended for diagnostic.