Phospho-PML Protein (Ser518) Recombinant Rabbit mAb
Product Name :
Phospho-PML Protein (Ser518) Recombinant Rabbit mAb
Cat.No.:
db14419
Synonyms :
MYL; RNF71; PP8675; TRIM19
Application :
WB, IHC
Reactivity :
Human, Mouse
Host species :
Rabbit
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Background
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Ser518 of human PML Protein
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Gene ID
5371
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Swiss Prot
P29590
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Synonyms
MYL; RNF71; PP8675; TRIM19
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Reactivity
Human, Mouse
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Application
WB, IHC
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Recommended dilution
WB: 1:1000
IHC: 1:50
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Calculated MW
98 kDa
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Observed MW
98,117 kDa
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Host species
Rabbit
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Clonality
Monoclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot detection of PML Protein (phospho-Ser518) in A549,HL-60,U2OS cell lysates using PML Protein (phospho-Ser518) antibody(1:1000 diluted).
订购信息
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Package
Price (RMB)
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20μL
698
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50μL
1398
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100μL
2398
- 货期:现货
For research use only. Not intended for diagnostic.