Ionotropic Glutamate receptor 2 Recombinant Rabbit mAb
Product Name :
Ionotropic Glutamate receptor 2 Recombinant Rabbit mAb
Cat.No.:
db14616
Synonyms :
GLUR2; GLURB; GluA2; HBGR2; GluR-K2
Application :
WB
Reactivity :
Human, Mouse, Rat
Host species :
Rabbit
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Background
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
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Immunogen
A synthetic peptide of human Ionotropic Glutamate receptor 2
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Gene ID
2891
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Swiss Prot
P42262
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Synonyms
GLUR2; GLURB; GluA2; HBGR2; GluR-K2
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Reactivity
Human, Mouse, Rat
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Application
WB
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Recommended dilution
WB: 1:1000
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Calculated MW
99 kDa
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Observed MW
99 kDa
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Host species
Rabbit
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Clonality
Monoclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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20μL
698
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50μL
1398
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100μL
2398
- 货期：现货
For research use only. Not intended for diagnostic.
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