IL1 Receptor I Recombinant Rabbit mAb - diagbio | 戴格生物

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IL1 Receptor I Recombinant Rabbit mAb

db14769

Product Name : IL1 Receptor I Recombinant Rabbit mAb

Cat.No.: db14769

Synonyms : IL-iR; CD121a; CD121b; IL-1R1; Il1r-1

Application : WB

Reactivity : Mouse

Host species : Rabbit

Background Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity).
Immunogen Recombinant protein of mouse IL1 Receptor I
Gene ID 16177
Swiss Prot P13504
Synonyms IL-iR; CD121a; CD121b; IL-1R1; Il1r-1
Reactivity Mouse
Application WB
Recommended dilution WB: 1:1000
Calculated MW 67 kDa
Observed MW 67,80 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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