53BP1 Recombinant Rabbit mAb - diagbio | 戴格生物

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53BP1 Recombinant Rabbit mAb

db15410

Product Name : 53BP1 Recombinant Rabbit mAb

Cat.No.: db15410

Synonyms : TP53; p202; 53BP1; TDRD30; p53BP1

Application : WB, IHC, ICC/IF, FC

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Immunogen A synthetic peptide of human 53BP1
Gene ID 7158
Swiss Prot Q12888
Synonyms TP53; p202; 53BP1; TDRD30; p53BP1
Reactivity Human, Mouse, Rat
Application WB, IHC, ICC/IF, FC
Recommended dilution WB: 1:1000-1:2000
IHC: 1:20-1:50
ICC/IF: 1:20-1:50
FC: 1:20
Calculated MW 214 kDa
Observed MW 450 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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