ZO-1 Recombinant Rabbit mAb - diagbio | 戴格生物

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ZO-1 Recombinant Rabbit mAb

db16102

Product Name : ZO-1 Recombinant Rabbit mAb

Cat.No.: db16102

Synonyms : TJP1; ZO1; Tight junction protein ZO-1; Tight junction protein 1

Application : IHC, ICC/IF, FC

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Immunogen Recombinant protein of human ZO-1
Gene ID 7082
Swiss Prot Q07157
Synonyms TJP1; ZO1; Tight junction protein ZO-1; Tight junction protein 1
Reactivity Human, Mouse, Rat
Application IHC, ICC/IF, FC
Recommended dilution IHC: 1:200-1:500
ICC/IF: 1:100
FC: 1:50
Calculated MW 195 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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