Phospho-Bcr (Tyr177) Rabbit pAb - diagbio | 戴格生物

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Phospho-Bcr (Tyr177) Rabbit pAb

db1676

Product Name : Phospho-Bcr (Tyr177) Rabbit pAb

Cat.No.: db1676

Synonyms : ALL; CML; PHL; BCR1; D22S11; D22S662

Application : WB

Reactivity : Human

Host species : Rabbit

Background A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Tyr177 of human Bcr
Gene ID 613
Swiss Prot P11274
Synonyms ALL; CML; PHL; BCR1; D22S11; D22S662
Reactivity Human
Application WB
Recommended dilution WB: 1:1000
Calculated MW 143 kDa
Observed MW 160 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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