Phospho-ATM (Ser1981) Rabbit pAb - diagbio | 戴格生物

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Phospho-ATM (Ser1981) Rabbit pAb

db171

Product Name : Phospho-ATM (Ser1981) Rabbit pAb

Cat.No.: db171

Synonyms : AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1

Application : WB, IHC, FC, IP

Reactivity : Human

Host species : Rabbit

Background The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser1981 of human ATM
Gene ID 472
Swiss Prot Q13315
Synonyms AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
Reactivity Human
Application WB, IHC, FC, IP
Recommended dilution WB: 1:2000
IHC: 1:50
FC: 1:20
IP: 1:20
Calculated MW 351 kDa
Observed MW 351 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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