Phospho-c-Met (Tyr1349) Rabbit pAb - diagbio | 戴格生物

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Phospho-c-Met (Tyr1349) Rabbit pAb

db20555

Product Name : Phospho-c-Met (Tyr1349) Rabbit pAb

Cat.No.: db20555

Synonyms : HGFR; AUTS9; RCCP2; c-Met; DFNB97

Application : WB, IHC, IP

Reactivity : Human

Host species : Rabbit

Background This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Tyr1349 of human Met
Gene ID 4233
Swiss Prot P08581
Synonyms HGFR; AUTS9; RCCP2; c-Met; DFNB97
Reactivity Human
Application WB, IHC, IP
Recommended dilution WB: 1:1000
IHC: 1:20
IP: 1:20
Calculated MW 156 kDa
Observed MW 170140 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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