Phospho-PAK4 (Ser474)/PAK5 (Ser602)/PAK6 (Ser560) Rabbit pAb - diagbio

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Phospho-PAK4 (Ser474)/PAK5 (Ser602)/PAK6 (Ser560) Rabbit pAb

db21550

Product Name : Phospho-PAK4 (Ser474)/PAK5 (Ser602)/PAK6 (Ser560) Rabbit pAb

Cat.No.: db21550

Application : WB, FC

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser474 of human PAK4
Gene ID 10298
56924
57144
Swiss Prot O96013
Q9NQU5
Q9P286
Reactivity Human, Mouse, Rat
Application WB, FC
Recommended dilution WB: 1:1000
FC: 1:1000
Calculated MW 64,81,75 kDa
Observed MW 72,82,90 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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