Product Name :
Aconitase 1 Rabbit pAb
Cat.No.:
db3244
Synonyms :
IRP1; ACONS; HEL60; IREB1; IREBP; IREBP1
Application :
WB, ICC/IF, FC
Reactivity :
Human, Mouse, Rat
Host species :
Rabbit
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Background
The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014]
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Immunogen
A synthetic peptide of human Aconitase 1
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Gene ID
48
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Swiss Prot
P21399
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Synonyms
IRP1; ACONS; HEL60; IREB1; IREBP; IREBP1
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Reactivity
Human, Mouse, Rat
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Application
WB, ICC/IF, FC
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Recommended dilution
WB: 1:1000
ICC/IF: 1:20-1:50
FC: 1:20
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Calculated MW
98 kDa
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Observed MW
98 kDa
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Host species
Rabbit
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Clonality
Polyclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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20μL
598
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50μL
998
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100μL
1798
- 货期：现货
For research use only. Not intended for diagnostic.
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