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Recombinant Human CD8A / MAL Protein (His tag)
db58581
Datasheet
- Background Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
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Gene ID
925
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Swiss Prot
P01732
- Synonyms CD8;CD8 alpha;Leu-2;Leu2;MAL;p32;p32 186910
- Application Positive Control, Immunogen, SDS-PAGE, WB
- Molecular Weight 19 kDa
- Species Human
- Expression Host HEK293 Cells
- Purity >90% as determined by SDS-PAGE.
- Seq Met 1-Asp 182
- Tag C-His
- Formulation Freeze-dried powder
- Storage/Stability Aliquot and store at -20℃ to -80℃ for up to 6 months. Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose; buffer containing 50% glycerol is recommen.
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15% SDS PAGE(reduced) analysis of Recombinant Human CD8A / MAL Protein (His tag)
订购信息
- Package Price (RMB)
- 10μg 860
- 50μg 1560
- 100μg 2560
- 1mg 14600
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
