BackgroundThis gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
ImmunogenA synthetic phosphopeptide corresponding to residues surrounding
Ser133 of human CREB
Storage/StabilityStore at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Western blot detection of Phospho-CREB (Ser133) in CHO-K1 cell lysates using Phospho-CREB (Ser133) antibody(1:500 diluted).
Immunohistochemical analysis of paraffin-embedded human lung cancer using db11133 antibody.