ABAT (DGR13445) Rabbit mAb - diagbio | 戴格生物

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Recombinant DGRmAb^®

ABAT (DGR13445) Rabbit mAb

db12293

Datasheet

Product Name : ABAT (DGR13445) Rabbit mAb

Cat.No.: db12293

Synonyms : GABAT; NPD009; GABA-AT

Application : WB, IHC-P, IP

Reactivity : Human,Mouse,Rat

Host species : Rabbit

Background 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Immunogen A synthetic peptide of human ABAT
Gene ID 18
Swiss Prot P80404
Synonyms GABAT; NPD009; GABA-AT
Reactivity Human,Mouse,Rat
Application WB, IHC-P, IP
Recommended dilution WB: 1:2000-1:20000
IHC-P: 1:200-1:1000
IP: 1:10-1:100
Calculated MW 56 kDa
Observed MW 56 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. DGR13445
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of ABAT/GABA-T in Rat Brain lysates using ABAT/GABA-T antibody(1:1000 diluted).

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