BackgroundThis gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]
ImmunogenA synthetic phosphopeptide corresponding to residues surrounding
Tyr279 of human GSK3 alpha
Storage/StabilityStore at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Western blot analysis of extracts from C6, 3T3 cell lysates using db13049 at 1:1000.
Western blot analysis of extracts from HCT116,RAW264.7 cells and Rat muscle tissue using db13049 at 1:1000.