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ORP150 (DGR13920) Rabbit mAb
db13502
Datasheet
- Background The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
- Immunogen A synthetic peptide of human ORP150
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Gene ID
10525
-
Swiss Prot
Q9Y4L1
- Synonyms Grp170; HSP12A; ORP150; GRP-170; ORP-150
- Reactivity Human
- Application WB, IHC, ICC/IF, FC, IP
-
Recommended dilution
WB: 1:1000-1:5000
IHC: 1:50-1:200
ICC/IF: 1:50-1:200
FC: 1:20
IP: 1:20-1:50 - Calculated MW 111 kDa
- Observed MW 150 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR13920
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot detection of ORP150 in Hela cell lysates using ORP150 antibody(1:1000 diluted). -
Immunohistochemical analysis of paraffin-embedded human colon cancer using db13502 antibody. -
Immunofluorescent analysis of HeLa cells using db13502 antibody (green), and DAPI (blue).
订购信息
- Package Price (RMB)
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
