alpha Actinin 4 (DGR13175) Rabbit mAb - diagbio | 戴格生物

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Recombinant DGRmAb^®

alpha Actinin 4 (DGR13175) Rabbit mAb

db13796

Datasheet

Product Name : alpha Actinin 4 (DGR13175) Rabbit mAb

Cat.No.: db13796

Synonyms : FSGS; FSGS1; ACTININ-4

Application : WB, IHC-P, ICC/IF, FC, IP

Reactivity : Human,Mouse,Rat

Host species : Rabbit

Background Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
Immunogen A synthetic peptide of human alpha Actinin 4
Gene ID 81
Swiss Prot O43707
Synonyms FSGS; FSGS1; ACTININ-4
Reactivity Human,Mouse,Rat
Application WB, IHC-P, ICC/IF, FC, IP
Recommended dilution WB: 1:1000-1:5000
IHC-P: 1:100-1:200
ICC/IF: 1:100-1:200
FC: 1:20-1:50
IP: 1:20-1:50
Calculated MW 105 kDa
Observed MW 105 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. DGR13175
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of alpha Actinin 4 in K562,Rat Brain,C6,3T3,Hela cell lysates using alpha Actinin 4 antibody(1:1000 diluted).
Western blot analysis of extracts from HepG2 cells and Rat liver，Mouse brain tissue using db13796 at 1:4000.
Immunofluorescent analysis of HeLa cells using db13796 antibody (green), and DAPI (blue).

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