Nicastrin Recombinant Rabbit mAb - diagbio | 戴格生物

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Nicastrin Recombinant Rabbit mAb

db14354

Product Name : Nicastrin Recombinant Rabbit mAb

Cat.No.: db14354

Synonyms : ATAG1874

Application : WB, FC, IP

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
Immunogen A synthetic peptide of human Nicastrin
Gene ID 23385
Swiss Prot Q92542
Synonyms ATAG1874
Reactivity Human, Mouse, Rat
Application WB, FC, IP
Recommended dilution WB: 1:1000
FC: 1:20
IP: 1:20
Calculated MW 78 kDa
Observed MW 110-120 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of Nicastrin in K562,Rat Brain,3T3,Hela cell lysates using Nicastrin antibody(1:1000 diluted).

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