Phospho-Presenilin 1 (Ser310) (DGR11353) Rabbit mAb - diagbio

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Recombinant DGRmAb^®

Phospho-Presenilin 1 (Ser310) (DGR11353) Rabbit mAb

db14695

Datasheet

Product Name : Phospho-Presenilin 1 (Ser310) (DGR11353) Rabbit mAb

Cat.No.: db14695

Synonyms : AD3; FAD; PS1; PS-1; S182

Application : WB

Reactivity : Human

Host species : Rabbit

Background Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser310 of human Presenilin 1
Gene ID 5663
Swiss Prot P49768
Synonyms AD3; FAD; PS1; PS-1; S182
Reactivity Human
Application WB
Recommended dilution WB: 1:1000
Calculated MW 53 kDa
Observed MW 22 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. DGR11353
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of Phospho-Presenilin 1/PS-1 (Ser310) in Jurkat,Hela cell lysates using Phospho-Presenilin 1/PS-1 (Ser310) antibody(1:1000 diluted).

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