5 Lipoxygenase Recombinant Rabbit mAb - diagbio | 戴格生物

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5 Lipoxygenase Recombinant Rabbit mAb

db15240

Product Name : 5 Lipoxygenase Recombinant Rabbit mAb

Cat.No.: db15240

Synonyms : 5-LO; 5LPG; LOG5; 5-LOX

Application : WB, IHC, ICC/IF, FC

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Immunogen A synthetic peptide of human 5 Lipoxygenase
Gene ID 240
Swiss Prot P09917
Synonyms 5-LO; 5LPG; LOG5; 5-LOX
Reactivity Human, Mouse, Rat
Application WB, IHC, ICC/IF, FC
Recommended dilution WB: 1:1000
IHC: 1:20-1:50
ICC/IF: 1:100
FC: 1:20-1:100
Calculated MW 78 kDa
Observed MW 78 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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