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Caspase-8 Rabbit pAb

Product Name : Caspase-8 Rabbit pAb

Cat.No.: db1571

Synonyms : CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8

Application : WB

Reactivity : Human

Host species : Rabbit

  • Background This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
  • Immunogen A synthetic peptide of human Caspase-8
  • Gene ID 841
  • Swiss Prot Q14790
  • Synonyms CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8
  • Reactivity Human
  • Application WB
  • Recommended dilution WB: 1:1000
  • Calculated MW 55 kDa
  • Observed MW 55 kDa
  • Host species Rabbit
  • Clonality Polyclonal
  • Isotype IgG
  • Purity Affinity Purification
  • Conjugation Un-conjugated
  • Storage/Stability Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
  • Package Price (RMB)
  • 20μL 598
  • 50μL 998
  • 100μL 1798
  • 货期:现货
For research use only. Not intended for diagnostic.