Product Name :
p21 Rabbit pAb
Cat.No.:
db162
Synonyms :
P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1
Application :
WB, IHC, ICC/IF, FC, IP
Reactivity :
Human
Host species :
Rabbit
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Background
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015]
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Immunogen
A synthetic peptide of human p21
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Gene ID
1026
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Swiss Prot
P38936
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Synonyms
P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1
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Reactivity
Human
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Application
WB, IHC, ICC/IF, FC, IP
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Recommended dilution
WB: 1:1000
IHC: 1:100-1:200
ICC/IF: 1:200
FC: 1:100
IP: 1:20
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Calculated MW
18 kDa
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Observed MW
21 kDa
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Host species
Rabbit
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Clonality
Polyclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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20μL
598
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50μL
998
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100μL
1798
- 货期：现货
For research use only. Not intended for diagnostic.
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