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Complement C5/C5b (DGR35349) Rabbit mAb
db16530
Datasheet
- Background This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
- Immunogen Recombinant protein of human Complement C5b
-
Gene ID
727
-
Swiss Prot
P01031
- Synonyms C5D; C5a; C5b; ECLZB; CPAMD4
- Reactivity Human, Mouse, Rat
- Application WB, IHC-P
-
Recommended dilution
WB: 1:1000
IHC-P: 1:2000-1:5000 - Calculated MW 188 kDa
- Observed MW 188, 70 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR35349
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
- Package Price (RMB)
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
