COL18A1 (DGR35698) Rabbit mAb - diagbio | 戴格生物

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Recombinant DGRmAb^®

COL18A1 (DGR35698) Rabbit mAb

db16570

Datasheet

Product Name : COL18A1 (DGR35698) Rabbit mAb

Cat.No.: db16570

Synonyms : KS; KNO; GLCC; KNO1

Application : WB, IHC-P, ICC/IF, FC, IP

Reactivity : Human

Host species : Rabbit

Background This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Immunogen Recombinant protein of human COL18A1
Gene ID 80781
Swiss Prot P39060
Synonyms KS; KNO; GLCC; KNO1
Reactivity Human
Application WB, IHC-P, ICC/IF, FC, IP
Recommended dilution WB: 1:1000
IHC-P: 1:1000-1:5000
ICC/IF: 1:50
FC: 1:200-1:500
IP: 1:20-1:50
Calculated MW 178 kDa
Observed MW 178 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. DGR35698
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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