Phospho-Smad1 (Ser463/Ser465) Rabbit pAb
Product Name :
Phospho-Smad1 (Ser463/Ser465) Rabbit pAb
Cat.No.:
db20386
Synonyms :
BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1
Application :
WB, IP
Reactivity :
Human, Mouse
Host species :
Rabbit
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Background
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
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Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Ser463/Ser465 of human Smad1
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Gene ID
4086
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Swiss Prot
Q15797
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Synonyms
BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1
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Reactivity
Human, Mouse
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Application
WB, IP
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Recommended dilution
WB: 1:1000
IP: 1:20
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Calculated MW
52 kDa
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Observed MW
52 kDa
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Host species
Rabbit
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Clonality
Polyclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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20μL
698
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50μL
1398
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100μL
2398
- 货期：现货
For research use only. Not intended for diagnostic.
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