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Nicastrin Rabbit pAb

Product Name : Nicastrin Rabbit pAb

Cat.No.: db2273

Synonyms : ATAG1874

Application : WB, ICC/IF

Reactivity : Human

Host species : Rabbit

  • Background This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
  • Immunogen A synthetic peptide of human Nicastrin
  • Gene ID 23385
  • Swiss Prot Q92542
  • Synonyms ATAG1874
  • Reactivity Human
  • Application WB, ICC/IF
  • Recommended dilution WB: 1:1000-1:5000
    ICC/IF: 1:20-1:50
  • Calculated MW 78 kDa
  • Observed MW 110-120 kDa
  • Host species Rabbit
  • Clonality Polyclonal
  • Isotype IgG
  • Purity Affinity Purification
  • Conjugation Un-conjugated
  • Storage/Stability Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
  • Package Price (RMB)
  • 20μL 598
  • 50μL 998
  • 100μL 1798
  • 货期:现货
For research use only. Not intended for diagnostic.