CTLA-4 Recombinant Rabbit mAb - diagbio | 戴格生物

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CTLA-4 Recombinant Rabbit mAb

db30157

Product Name : CTLA-4 Recombinant Rabbit mAb

Cat.No.: db30157

Application : IHC, WB

Reactivity : Human

Host species : Rabbit

Background Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a member of the CD28 superfamily and is a negative regulator of T cell-mediated immune responses. CTLA-4 expression is induced on the surface of T cells after CD28 binding and activation, and is constitutively expressed on T-regulatory cells, acting as an immune checkpoint inhibitor, downregulating T cell activity. CTLA-4 primarily inactivates T-cell activity by competing with the CD28 costimulatory molecule. CD28 and CTLA-4 share the identical ligands of CD80 and CD86 on antigenpresenting cells; and thus CTLA-4 competes with CD28 function in T-cell survival, proliferation, and recruitment.
Immunogen Synthetic peptide within Human CTLA-4
Swiss Prot P16410
Reactivity Human
Application IHC, WB
Recommended dilution IHC: 1:100-1:200
Calculated MW 25 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. BP6187
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Immunohistochemistry of paraffin-embedded human tonsil using CTLA-4 antibody at dilution of 1:200 (200x lens).

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