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CTLA-4 (BP6187) Rabbit mAb
db30157
Datasheet
- Background Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a member of the CD28 superfamily and is a negative regulator of T cell-mediated immune responses. CTLA-4 expression is induced on the surface of T cells after CD28 binding and activation, and is constitutively expressed on T-regulatory cells, acting as an immune checkpoint inhibitor, downregulating T cell activity. CTLA-4 primarily inactivates T-cell activity by competing with the CD28 costimulatory molecule. CD28 and CTLA-4 share the identical ligands of CD80 and CD86 on antigenpresenting cells; and thus CTLA-4 competes with CD28 function in T-cell survival, proliferation, and recruitment.
- Immunogen Synthetic peptide within Human CTLA-4
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Swiss Prot
P16410
- Reactivity Human
- Application IHC, WB
- Recommended dilution IHC: 1:100-1:200
- Calculated MW 25 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. BP6187
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Immunohistochemistry of paraffin-embedded human tonsil using CTLA-4 antibody at dilution of 1:200 (200x lens).
订购信息
- Package Price (RMB)
- 100μL 3240
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
