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LAG-3 (BP6192) Rabbit mAb
db30159
Datasheet
- Background Lymphocyte activation gene 3 (LAG-3, CD223) is an immune checkpoint control protein that negatively regulates T cells and immune responses. A CD4-like member of the Ig superfamily, LAG3 contains an extracellular IgV and three IgC domains, a transmembrane domain, and a short cytoplasmic region. LAG3 is primarily expressed by activated CD4+ T cells, CD8+ T cells, Tregs and NK cells, where it's activated by MHC Class II molecules, its only known ligand. While it was initially shown to activate Treg cells, LAG3 can also inhibit CD8+ T cells.
- Immunogen Synthetic peptide within Human LAG-3
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Swiss Prot
P18627
- Synonyms CD223
- Reactivity Human
- Application IHC, WB
- Recommended dilution IHC: 1:100-1:200
- Calculated MW 57 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. BP6192
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Immunohistochemistry of paraffin-embedded human lymphoma using LAG-3 antibody at dilution of 1:200 (200x lens).
订购信息
- Package Price (RMB)
- 100μL 3600
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
