GATA-3 Recombinant Rabbit mAb - diagbio | 戴格生物

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GATA-3 Recombinant Rabbit mAb

db30187

Product Name : GATA-3 Recombinant Rabbit mAb

Cat.No.: db30187

Synonyms : HDR; HDRS

Application : IHC, WB

Reactivity : Human

Host species : Rabbit

Background GATA binding protein 3 or GATA-3, is a zinc finger transcription factor and plays an important role in promoting and directing cell proliferation, development, and differentiation in many tissues and cell types. GATA-3 is one of the three genes mutated in 10% of breast cancers. Nuclear expression of GATA-3 in breast cancer is considered a marker of luminal cancer in ER+ cancer and luminal androgen responsive cancer in ER-/AR+ tumors. It is highly coexpressed with FOXA1 and serves as negative predictor of basal subtype and HER-2 and is also considered a strong predictor of taxane and platin salts insensitivity.
Immunogen Synthetic peptide. This information is proprietary to Biolynx
Swiss Prot P23771
Synonyms HDR; HDRS
Reactivity Human
Application IHC, WB
Recommended dilution IHC: 1:100-1:200
Calculated MW 48 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. BP6229
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Immunohistochemistry of paraffin-embedded human breast cancer using GATA-3 antibody at dilution of 1:200 (200x lens).

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