HLA-G (BP6247) Rabbit mAb - diagbio | 戴格生物

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Recombinant

HLA-G (BP6247) Rabbit mAb

db30203

Datasheet

Product Name : HLA-G (BP6247) Rabbit mAb

Cat.No.: db30203

Application : IHC, WB

Reactivity : Human

Host species : Rabbit

Background HLA-G (HLA-G histocompatibility antigen, class I, G) is a non-classical MHC molecule expressed by trophoblasts in placenta, thymic epithelial cells, and some tumors. Alternative splicing leads to generation of at least six isoforms, four that are transmembrane proteins and two that are soluble. It is an inhibitory molecule involved in immune tolerance and escape, originally studied for its role in maternal tolerance of the fetus during pregnancy. HLA-G binds ILT2, ILT4, and KIR2DL4, playing a role in the regulation of natural killer, T, and monocyte/macrophage cells. Its involvement in evasion of immune response makes it a potential target for immunotherapy.
Immunogen Recombinant protein fragment of human HLA-G was used as an immunogen
Swiss Prot P17693
Reactivity Human
Application IHC, WB
Recommended dilution IHC: 1:100-1:200
Calculated MW 38 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. BP6247
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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