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53BP1 Rabbit pAb

Product Name : 53BP1 Rabbit pAb

Cat.No.: db3036

Synonyms : TP53; p202; 53BP1; TDRD30; p53BP1

Application : WB, IHC, ICC/IF, FC

Reactivity : Human, Mouse, Rat

Host species : Rabbit

  • Background This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
  • Immunogen A synthetic peptide of human 53BP1
  • Gene ID 7158
  • Swiss Prot Q12888
  • Synonyms TP53; p202; 53BP1; TDRD30; p53BP1
  • Reactivity Human, Mouse, Rat
  • Application WB, IHC, ICC/IF, FC
  • Recommended dilution WB: 1:1000-1:2000
    IHC: 1:20-1:50
    ICC/IF: 1:20-1:50
    FC: 1:20
  • Calculated MW 214 kDa
  • Observed MW 450 kDa
  • Host species Rabbit
  • Clonality Polyclonal
  • Isotype IgG
  • Purity Affinity Purification
  • Conjugation Un-conjugated
  • Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
  • Package Price (RMB)
  • 20μL 598
  • 50μL 998
  • 100μL 1798
  • 货期:现货
For research use only. Not intended for diagnostic.