GSDMD Rabbit pAb - diagbio | 戴格生物

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GSDMD Rabbit pAb

db3345

Product Name : GSDMD Rabbit pAb

Cat.No.: db3345

Synonyms : DF5L; M2-4; Dfna5l; Gsdmdc1; AW558049; 1810036L03Rik

Application : WB, IP

Reactivity : Mouse

Host species : Rabbit

Background Gasdermin-D, N-terminal: Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26611636, PubMed:26375259, PubMed:26375003, PubMed:27418190, PubMed:27385778, PubMed:27383986). After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-trisphosphate, and more weakly to phosphatidic acid and phosphatidylserine.
Immunogen A synthetic peptide of mouse GSDMD
Gene ID 69146
Swiss Prot Q9D8T2
Synonyms DF5L; M2-4; Dfna5l; Gsdmdc1; AW558049; 1810036L03Rik
Reactivity Mouse
Application WB, IP
Recommended dilution WB: 1:1000
IP: 1:20
Calculated MW 53 kDa
Observed MW 53 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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