Phospho-PKA alpha/beta/gamma (catalytic subunit) (Thr197) Rabbit pAb - diagbio

产品中心 Products Center

您当前的位置：

Phospho-PKA alpha/beta/gamma (catalytic subunit) (Thr197) Rabbit pAb

db3644

Datasheet

Product Name : Phospho-PKA alpha/beta/gamma (catalytic subunit) (Thr197) Rabbit pAb

Cat.No.: db3644

Synonyms : PKACA; PPNAD4

Application : WB, IHC, ICC/IF, IP

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Tyr197 of human PKA alpha/beta/gamma (catalytic subunit)
Gene ID 5566
Swiss Prot P17612
Synonyms PKACA; PPNAD4
Reactivity Human, Mouse, Rat
Application WB, IHC, ICC/IF, IP
Recommended dilution WB: 1:1000
IHC: 1:20-1:50
ICC/IF: 1:20-1:100
IP: 1:20
Calculated MW 41 kDa
Observed MW 41 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

订购信息

Package Price (RMB)
20μL 698
50μL 1398
100μL 2398
货期：现货