Phospho-AMPK alpha 2 (Ser491) Rabbit pAb - diagbio | 戴格生物

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Phospho-AMPK alpha 2 (Ser491) Rabbit pAb

db4248

Product Name : Phospho-AMPK alpha 2 (Ser491) Rabbit pAb

Cat.No.: db4248

Synonyms : AMPK; AMPK2; PRKAA; AMPKa2

Application : WB

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser491 of human AMPK alpha 2
Gene ID 5563
Swiss Prot P54646
Synonyms AMPK; AMPK2; PRKAA; AMPKa2
Reactivity Human, Mouse, Rat
Application WB
Recommended dilution WB: 1:1000-1:5000
Calculated MW 62 kDa
Observed MW 62 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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