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Raf1 Rabbit pAb

Product Name : Raf1 Rabbit pAb

Cat.No.: db4640

Synonyms : NS5; CRAF; Raf-1; c-Raf; CMD1NN

Application : WB, IHC, ICC/IF

Reactivity : Human

Host species : Rabbit

  • Background This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
  • Immunogen A synthetic peptide of human Raf1
  • Gene ID 5894
  • Swiss Prot P04049
  • Synonyms NS5; CRAF; Raf-1; c-Raf; CMD1NN
  • Reactivity Human
  • Application WB, IHC, ICC/IF
  • Recommended dilution WB: 1:1000
    IHC: 1:20
    ICC/IF: 1:20
  • Calculated MW 73 kDa
  • Observed MW 73 kDa
  • Host species Rabbit
  • Clonality Polyclonal
  • Isotype IgG
  • Purity Affinity Purification
  • Conjugation Un-conjugated
  • Storage/Stability Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
  • Package Price (RMB)
  • 20μL 598
  • 50μL 998
  • 100μL 1798
  • 货期:现货
For research use only. Not intended for diagnostic.