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Acetyl-p53 (Lys382) (3E3) Mouse mAb

Product Name : Acetyl-p53 (Lys382) (3E3) Mouse mAb

Cat.No.: db6592

Synonyms : Cellular tumor antigen p53; Cys 51 stop; Tp53; Tumor protein p53

Application : IHC-P

Reactivity : Human, Rat, Mouse

Host species : Mouse

  • Background Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed/24051492).
  • Immunogen Synthetic peptide conjugated to KLH
  • Gene ID 7157
  • Swiss Prot P04637
  • Synonyms Cellular tumor antigen p53; Cys 51 stop; Tp53; Tumor protein p53
  • Reactivity Human, Rat, Mouse
  • Application IHC-P
  • Recommended dilution IHC: 1:50-1:100
  • Calculated MW 53 kDa
  • Host species Mouse
  • Clonality Monoclonal
  • Clonality No. 3E3-3C4-7G5
  • Isotype IgG1
  • Purity Affinity Purification
  • Conjugation Un-conjugated
  • Storage/Stability Store at -20°C. Supplied in PBS, 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Stable for 12 months from date of receipt.
  • Immunohistochemistry analysis of paraffin-embedded Human Colon Carcinoma Tissue using Acetyl-p53 (Lys382) (3E3) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
  • Immunohistochemical analysis of paraffin-embedded Human tonsils using Acetyl-p53 (Lys382) (3E3) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
订购信息
  • Package Price (RMB)
  • 50μL 1398
  • 100μL 2398
  • 货期:现货
For research use only. Not intended for diagnostic.