ATG7 (1F8) Mouse mAb - diagbio | 戴格生物

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ATG7 (1F8) Mouse mAb

db6594

Product Name : ATG7 (1F8) Mouse mAb

Cat.No.: db6594

Synonyms : hAGP7; Ubiquitin-activating enzyme E1-like protein; APG7L

Application : IHC-P

Reactivity : Human, Rat, Mouse

Host species : Mouse

Background E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.
Immunogen Purified recombinant protein expressed in E.coli
Gene ID 10533
Swiss Prot O95352
Synonyms hAGP7; Ubiquitin-activating enzyme E1-like protein; APG7L
Reactivity Human, Rat, Mouse
Application IHC-P
Recommended dilution IHC: 1:50-1:100
Calculated MW 78 kDa
Host species Mouse
Clonality Monoclonal
Clonality No. 1F8-8H4-4G10
Isotype IgG1
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in PBS, 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Stable for 12 months from date of receipt.

Immunohistochemistry analysis of paraffin-embedded Human Breast Carcinoma Tissue using ATG7 (1F8) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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