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Phospho-Cyclin D1 (Thr286)/Cyclin D2 (Thr280) Rabbit pAb

Product Name : Phospho-Cyclin D1 (Thr286)/Cyclin D2 (Thr280) Rabbit pAb

Cat.No.: db9120

Synonyms : BCL1; PRAD1; U21B31; D11S287E

Application : WB

Reactivity : Human, Mouse, Rat

Host species : Rabbit

  • Background The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019]
  • Immunogen A synthetic phosphopeptide corresponding to residues surrounding Thr286 of human Cyclin D1
  • Gene ID 595
  • Swiss Prot P24385
  • Synonyms BCL1; PRAD1; U21B31; D11S287E
  • Reactivity Human, Mouse, Rat
  • Application WB
  • Recommended dilution WB: 1:1000
  • Calculated MW 34 kDa
  • Observed MW 36 kDa
  • Host species Rabbit
  • Clonality Polyclonal
  • Isotype IgG
  • Purity Affinity Purification
  • Conjugation Un-conjugated
  • Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
  • Package Price (RMB)
  • 20μL 698
  • 50μL 1398
  • 100μL 2398
  • 货期:现货
For research use only. Not intended for diagnostic.