Phospho-ATG16L1 (Ser278) Rabbit pAb - diagbio | 戴格生物

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Phospho-ATG16L1 (Ser278) Rabbit pAb

db9350

Product Name : Phospho-ATG16L1 (Ser278) Rabbit pAb

Cat.No.: db9350

Synonyms : WDR30; Apg16l; Atg16l; 1500009K01Rik

Application : WB

Reactivity : Mouse

Host species : Rabbit

Background Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:18849966, PubMed:12665549, PubMed:24954904, PubMed:24553140, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (By similarity). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway. Plays a role in regulating morphology and function of Paneth cell.
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser278 of mouse ATG16L1
Gene ID 77040
Swiss Prot Q8C0J2
Synonyms WDR30; Apg16l; Atg16l; 1500009K01Rik
Reactivity Mouse
Application WB
Recommended dilution WB: 1:1000
Calculated MW 68 kDa
Observed MW 68 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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