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SIRP alpha (DGR32481) Rabbit mAb
db11691
Datasheet
- Background The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]
- Immunogen Recombinant protein of human SIRP alpha
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Gene ID
140885
-
Swiss Prot
P78324
- Synonyms BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1
- Reactivity Human
- Application WB, IHC-P, ICC/IF, FC
-
Recommended dilution
WB: 1:1000
IHC-P: 1:200-1:500
ICC/IF: 1:100-1:200
FC: 1:200-1:500 - Calculated MW 55 kDa
- Observed MW 85 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR32481
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot detection of SIRP alpha in A549,MCF-7,293T cell lysates using SIRP alpha antibody(1:1000 diluted). -
Immunofluorescent analysis of HeLa cells using db11691 antibody (green), and DAPI (blue).
订购信息
- Package Price (RMB)
- 10μL 398
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
