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Phospho-E-Cadherin (Ser838/Ser840) (DGR31265) Rabbit mAb
db11988
Datasheet
- Background This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
- Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser838/Ser840 of human E-Cadherin
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Gene ID
999
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Swiss Prot
P12830
- Synonyms UVO; CDHE; ECAD; LCAM; Arc-1; BCDS1; CD324
- Reactivity Human,Mouse,Rat
- Application WB, IHC-P
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Recommended dilution
WB: 1:1000-1:5000
IHC-P: 1:5000-1:50000 - Calculated MW 98 kDa
- Observed MW 135 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR31265
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot detection of E Cadherin (phospho-Ser838/Ser840) in HepG2,U2OS,U251,Lncap using E Cadherin (phospho-Ser838/Ser840) antibody(1:1000 diluted) -
Immunohistochemical analysis of paraffin-embedded human breast cancer using db11988 antibody.
订购信息
- Package Price (RMB)
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
