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Bcr (DGR31118) Rabbit mAb
db12204
Datasheet
- Background A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020]
- Immunogen A synthetic peptide of human Bcr
-
Gene ID
613
-
Swiss Prot
P11274
- Synonyms ALL; CML; PHL; BCR1; D22S11; D22S662
- Reactivity Human
- Application WB, IHC-P, ICC/IF
-
Recommended dilution
WB: 1:1000-1:5000
IHC-P: 1:50-1:100
ICC/IF: 1:100-1:200 - Calculated MW 143 kDa
- Observed MW 160 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR31118
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot detection of Bcr in A549,HL-60,U2OS,C6 cell lysates using Bcr antibody(1:1000 diluted). -
Immunohistochemical analysis of paraffin-embedded human Brain using db12204 antibody.
订购信息
- Package Price (RMB)
- 10μL 398
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
