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SFPQ (DGR19159) Rabbit mAb
db12226
Datasheet
- Background DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion.
- Immunogen A synthetic peptide of human SFPQ
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Gene ID
6421
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Swiss Prot
P23246
- Synonyms PSF; POMP100; PPP1R140
- Reactivity Human,Mouse,Rat
- Application WB, IHC-P, ICC/IF, FC
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Recommended dilution
WB: 1:2000-1:20000
IHC-P: 1:1000-1:10000
ICC/IF: 1:50-1:100
FC: 1:20-1:50 - Calculated MW 76 kDa
- Observed MW 100 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR19159
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot detection of SFPQ in K562,Rat Brain,C6,3T3,Hela cell lysates using SFPQ antibody(1:1000 diluted). -
Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using db12226 antibody. -
Immunofluorescent analysis of 293T cells using db12226 antibody (green), and DAPI (blue).
订购信息
- Package Price (RMB)
- 10μL 398
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
